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Glipizide (Glucotrol) Uses and Side Effects

By | Diabetes, Sulfonylureas | No Comments

Glipizide is an antidiabetic drug of the chemical sulfonylurea class.  It is an oral and short acting drug that is classified as a second generation sulfonylurea.  It is marketed by Pfizer under the name Glucotrol in the United States. 

How Does Glipizide Work?

Like other sulfonylurea antidiabetic medicines, glipizide induces insulin release from pancreatic beta cells, but only when there is some beta-cell activity remaining in the pancreas.  This helps control blood sugar to maintain it at normal levels.  Glipizide is used with diet and exercise to have a healthy lifestyle with your type II diabetes diagnosis.  Some patients cannot take glipizide: If you have blockage in your intestines, kidney or liver disease, or a history of heart disease.  Tell your doctor if you have a glucose-6-phosphate deficiency (G6PD), a disorder of the pituitary or adrenal glands.

Warnings and Side Effects

Some oral diabetes drugs can increase your risk of serious heart issues.  Not taking your diabetes drugs have damage your heart and other organs, so you should talk to your physician about your risks. Other side effects of the sulfonylurea class of diabetes drugs include: low blood sugar symptoms such as dizziness, confusion, sweating, nervousness, weight gain, upset stomach, hunger, skin reactions, and dark urine.

How Do Genetics Determine Drug Metabolism?

Since the human genome was completed, many genome wide association studies have revealed that there are variations in the many genes that are responsible for processing drugs. processing in your body is also called drug metabolism.  Genes provide ‘instructions’ for the production of the actual enzymes responsible for drug metabolism.  Thus, variations in the genes transfer to the enzyme, which will have variations from the genetic instructions.  Variations in the enzyme may mean that the drug metabolism function is altered.  That could mean that the enzyme responsible for metabolizing several or a number of drugs isn’t working properly, resulting in side effects. 

Genetic Testing with Rxight®

One important way to know beforehand if you have any drug metabolism variations is to get the Rxight® pharmacogenetics test from MD Labs.  With one simple cheek swab, you and your physician can have at hand the results of this state-of-the-art platform that reveals your genetic disposition to any of the 200 drugs and over-the-counter products on the market.


To avoid side effects or medication inefficacy, ask your physician to prescribe the Rxight® pharmacogenetics test from MD Labs.  All that is required is a participating pharmacy and your physician’s prescription.  It also brings precision medicine to you and your physician, utilizing more individualized medical care.