Description: The meglitinides are a class of medications used to lower glucose levels in the blood. As such, their one type of medicine used to treat people with type II diabetes. There are three meglitinides on the market: repaglinide (Prandin), nateglinide (Starlix), and mitiglinide (Glufast).
Common side effects of meglitinides include:
All meglitinides work in the same way, by causing the pancreas to secrete insulin. Increased insulin drives glucose from the blood into cells. This effect is helpful in type II diabetes, but for individuals who metabolize these medications quickly, it may also lead to one of the potentially fatal meglitinides side effects – hypoglycemia. Very severe hypoglycemia may cause seizures, coma, and death.
Understand Your Risks with the Rxight® Genetic Test
The Rxight® genetic test is based on the analysis of gene variants that affect how hundreds of over-the-counter and prescription medications work. The DNA testing is done by taking a simple non-invasive sample from a cheek swab and sending it for processing, where 18 genes and their alleles are tested across over 40 clinically significant medication classes, including meglitinides. Each patient receives a Personalized Medication Review® by a pharmacist trained in pharmacogenetics to share with your prescriber(s) .
How Does Pharmacogenetic Testing Work?
Your unique genetic makeup influences the way you metabolize medications, including meglitinides. For most people, the drug level will be fairly predictable. However, for people with certain genetic differences in liver enzymes, the level of drug may be too high or too low, which may cause adverse reactions such as hypoglycemia, or inefficacy. Rxight® pharmacogenetic testing is based on an extensive analysis of patient’s unique genetic makeup. Genes tested in this panel include those important in the metabolism of meglintinides. Through pharmacogenetic (PGx) testing, you can determine if you have the gene variants that make these liver enzymes more or less active. This information could be invaluable for your healthcare provider when making diabetes treatment decisions and in managing meglitinides side effects.
Contributors to this Article:
Michael Sapko, MD, PhD; Deborah Kallick, PhD, Medicinal Chemistry
Meglitinides Tested Include:
Read more about Rxight® Genetic Testing For Medication Effectiveness