Description: A nonsteroidal anti-inflammatory drug, or simply “NSAID,” is commonly used to treat mild to moderate pain and fever. Some NSAID side effects are caused by the same process that provides a benefit – it work by blocking the synthesis of certain chemicals in the body that allows the body to process and create the sensation of pain. Many NSAIDs are available over-the-counter and are generally safe for most people. However, some people are unable to take this type of medication because the side effects are severe and even life-threatening.
Common and Serious Side Effects of NSAIDs
Common NSAID side effects include: headaches, dizziness, ringing in the ears (tinnitus), high blood pressure and swelling in the legs. People who take NSAIDs for a long time may develop kidney or liver problems. In fact, people who have chronic kidney disease should not take these drugs because of NSAID adverse reaction to the kidney. Likewise, people with chronic liver disease may have an increased risk of bleeding in the gastrointestinal tract if they take NSAIDs. Aspirin side effects include blood thinning. Non-aspirin NSAIDs increase the risk of heart attack and stroke.
Understand Your Risks with the Rxight® Genetic Test
Rxight® DNA testing provides patients with their individualized analysis of 18 genes and alleles which modulate liver enzymes involved in the metabolism of hundreds of clinically relevant medications across 40 pharmacological classes, including NSAIDs. The Rxight® genetic test provides patients with their genotype in one convenient test panel, along with a detailed analysis of how they metabolize medications, which will be reviewed with you by a pharmacist.
How Does Pharmacogenetic Testing Work?
Pharmacogenetic testing is relatively new field that has emerged from the sequencing of the human genome. Research shows that some people have variations in their genes that process (metabolize) medicines. Depending on the variation, you may experience adverse reactions or respond to the drug appropriately. Thus, with the Rxight® genetic test, you and your pharmacist can determine whether or not your respond to the medication before it is used.
Contributors to this Article:
Michael Sapko, MD, Phd and Deborah Kallick, PhD, Medicinal Chemistry
NSAIDs Tested Include:
- Celecoxib (Celebrex)
- Diclofenac (Cataflam)
- Flurbiprofen (Ansaid)
- Ibuprofen (Advil, Motrin)
- Indomethacin (Indocin, Tivorbex)
- Ketoprofen (Orudis, Actron, Oruvail, Nexcede)
- Ketorolac (Toradol, Sprix)
- Meloxicam (Mobic)
- Nabumetone (Relafen)
- Naproxen (Aleve, Naprosyn, Anaprox)
- Piroxicam (Feldene)
- Sulindac (Clinoril)
Read more about Rxight® Genetic Testing For Drug Metabolism