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Side Effects of
Signal Transduction Inhibitors


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Description: A signal transduction inhibitor is a drug that blocks signals passed from one molecule to another inside a cell. Blocking a signal affects many functions of the cell, including cell division, cell death, and may kill cancer cells. In fact, signal transduction inhibitors may prevent the ability of cancer cells to multiply quickly and invade other tissues.

How Do Signal Transduction Inhibitors Work?

Cancer cells have less signaling networks, and therefore, tend to have fewer signaling activities than non-cancerous cells. Signal transduction inhibition is a specific type of targeted therapy and it held the promise of better efficacy with fewer side effects. Targeted therapy is different from standard chemotherapy as the therapies act on specific molecular targets that are associated with cancer, whereas, most standard chemotherapies act on all rapidly dividing normal and cancerous cells.

Signal Transduction Serious Side Effects and Warnings

Severe side effects include:

  • Interstitial lung disease
  • Liver damage
  • Gastrointestinal perforation
  • Subungual splinter hemorrhages
  • Common Side Effects

    Other side effects include:

  • Diarrhea
  • Skin problems (hair depigmentation, acne type rash, dry skin)
  • Complications with wound healing
  • Blood clotting
  • Puffy eyes
  • Understand Your Risks with the Rxight® Pharmacogenetic Test

    Pharmacogenetics plays a role in your cancer treatment. Drugs administered during therapy may have side effects that differ from cancer medications. Pharmacogenetics research shows that variations in drug processing genes are common, and that these variations result in diversity in the drug’s response. The Rxight®genetic test from MD Labs is the most comprehensive pharmacogenetic test available. It is designed to measure how you will respond to hundreds of medications, both over-the-counter and prescription, based on your unique genotype. All that is required is a simple cheek swab from a participating pharmacy. The results of this test can then be shared with your physician, who can then better determine what drugs you may safely use.


    Contributors to this Article:
    Michael Sapko, MD, PhD; Deborah Kallick, PhD, Medicinal Chemistry


    Signal Transduction Inhibitors Tested Include:

    Read more about Rxight® DNA Testing For Medication Tolerance