Side Effects of Flurbiprofen (Ansaid)
Flurbiprofen, available under the brand Ansaid, is an NSAID (non steroidal anti-inflammatory drug) that has anti-inflammatory, analgesic and antipyretic (lowers fever) properties. The mechanism of Ansaid is not known. However, it is suggested that Ansaid is related to the inhibition of prostaglandin, an inflammatory hormone, and also related to cyclooxygenase (COX). Ansaid is used to treat pain, swelling, tenderness, and joint stiffness from osteoarthritis (chronic condition of the joints) and rheumatoid arthritis (chronic inflammation of the joints). Each tablet for oral administration contains 50 mg or 100 mg of Flurbiprofen.
Serious Side Effects
Severe side effects are possible with NSAIDS, including Ansaid. The Ansaid label reported by the FDA advises Ansaid may cause an increased risk of cardiovascular thrombotic events, including myocardial infarction (heart attack) and stroke, which can be fatal.
There is also a risk of serious gastrointestinal (GI) adverse events. GI events include bleeding, ulceration, and perforation (severe pain) of the stomach or intestines, which can be fatal. Extra caution should be taken since these adverse reactions may occur without warning symptoms during Ansaid treatment.
Those at an increased risk for these severe GI events are the elderly and those with a history of peptic ulcer disease and GI bleeding.
Common Side Effects
The common side effects of Ansaid are:
- Stomach pain
- Mild heartburn
- Upset stomach
- Dry mouth
- Skin itching or rash
- Blurred vision
- Ringing in your ears
About Pharmacogenetic Testing
Studies have established that the metabolism of Ansaid takes place in the cythocrome 450, specifically in the gene polymorphism CYP2C9. Studies have concluded those with poor CYP2C9 metabolizing activity or history with other CYP2C9 substrates, like Warfarin and Phenytoin, should be given Ansaid with caution. These types of patients may possess abnormally high plasma levels because of reduced metabolic clearance.
Know Your Risk with the Rxight® Genetic Test
Rxight® genetic testing analyzes 18 genes on 60 alleles to provide patients with a personalized analysis of how their genetic profile responds to drugs. This easy to understand, accurate, and reliable test demonstrates how medications may or may not metabolize drugs effectively or are harmful to you. With your results from the Rxight test, your health care provider will be able to construct a plan with your genetic information saving you money, time, and most importantly, prevent adverse drug reactions.
Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry
Read more about Rxight® : What Is PGx Testing?