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Side Effects of Apixaban (Eliquis)


Apixaban, often referred to by its trade name Eliquis, is an anticoagulant drug. It is commonly used for lowering risk of stroke and treatment of deep vein thrombosis (blood clot in the vein) and shortness of breath.

Serious Side Effect of Eliquis: Uncontrolled Bleeding

Eliquis can cause bleeding which can be serious and may be fatal (Eliquis Medication Guide, June 2015 as reported by the FDA). This is because it is a blood thinner medicine that reduces blood clotting. Report the following to your doctor immediately:

  • Hematuria (blood in urine as indicated by red, pink or brown color)
  • Gingival bleeding (bleeding from gums)
  • Nosebleeds that happen often
  • Bleeding that is severe or you cannot control
  • Coughing up blood or blood clots
  • Blood in vomit
  • Eye haemorrhage (bleed)
  • Other Serious Side Effects of Eliquis

    Other severe side effects Eliquis (apixaban) according to the Eliquis (apixaban) label, as reported by the FDA include:

  • Atrial fibrillation (irregular or fast heartbeat)
  • Syncope (fainting)
  • Peripheral edema (swelling in extremities)
  • Tachycardia (increased heart rate)
  • Diabetes Mellitus
  • Stroke
  • Hypotension (low blood pressure)
  • Cataract (clouding of lens of the eye)
  • Dyspnea (difficulty breathing)
  • Hyperglycemia (Blood glucose increased mainly in diabetes patients)
  • Common Side Effects of Eliquis

    The most common side effects of Eliquis include minor bleeding in about 12% of patients, anemia (including postoperative), sinusitis (sinus infection), pneumonia, influenza, urinary tract infection, menorrhagia (heavy bleeding during menstruation), dyspepsia (indigestion), and gastritis (inflammation of the stomach). Other common side effects are dizziness that could lead to vertigo, headache, fatigue, nausea, constipation, vomiting, diarrhea, abdominal pain, toothache, and rash.

    Understand Your Risks with the Rxight® Genetic Test

    The Rxight® pharmacogenetic test determines how well you metabolize Eliquis and over 200 other prescription and OTC medications. If you metabolize Eliquis more slowly than normal, you are at risk for side effects and toxicity – in the case of Eliquis, you would be at risk for severe bleeding. If you are a fast metabolizer, you process the medication quickly, meaning it may not be effective for you at standard doses – in the case of Eliquis, putting you at risk for a stroke.
    Email us or call 1 (888) 888-1932 to get started with Rxight® today.

    Contributors to this Article:
    Michael Sapko, MD, PhD; Deborah Kallick, PhD, Medicinal Chemistry

    Read more about Rxight® Drug Sensitivity Testing