Side Effects of Eliglustat (Cerdelga)
Eliglustat, also known as the brand Cerdelga, is a treatment for Gaucher’s disease, a rare genetic disorder causing fat to build up in cells and certain organs in the body.
Cerdelga can be used as a long term treatment to improve Gaucher’s disease Type 1 symptoms such as bruising, tiredness, pain in the joints or bones, and swollen liver or spleen. Before using this medication inform your health care provider if you have kidney disease or any problems with your liver.
Serious Side Effects
Cerdelga may cause a heart rhythm condition called QT prolongation. Although rare, QT prolongation can cause serious fast or irregular heartbeat and other symptoms (such as severe dizziness or fainting) that need medical attention. Low magnesium or potassium may contribute to your risk for QT prolongation. Tell your doctor about any drugs you may be currently taking.
Common Side Effects
According to the FDA, the common side effects of Cerdelga are:
- Back pain
- Joint pain
- Mouth or throat irritation
- Pain in the arms or legs
- Stomach pain
About Pharmacogenetic Testing
Cerdelga is a CYP2D6 and CYP3A substrate. Research has found that the combination of CYP2D6 and CYP3A inhibitors may increase the risks of arrhythmias (slow or irregular heartbeats). The FDA indicates that CYP2D6 ultra-rapid metabolizers, those who metabolize drugs fast resulting in not receiving the full effects of the drug, may achieve the therapeutic effect of Cerdelga. The FDA also finds that a specific dosage cannot be determined for intermediate metabolizers.
Pharmacogenetics is the study of genetic variation among large populations in drug metabolizing genes. These genes produce the enzymes that metabolize most drugs on the market. The results of this test can inform your physician about genetic variations in your drug metabolism genes that may affect your ability to properly metabolize most drugs on the market.
Know Your Risk for Side Effects with the Rxight® Genetic Test
The Rxight® test identifies polymorphisms on more than 18 genes on 60 alleles. Identifying these polymorphisms before starting a medication can assist physicians and pharmacists in designing the best treatment plan for you.
With the Rxight pharmacogenetics test, your physician and pharmacist can employ precision medicine to your care by having results that inform how medications, such as Cerdelga, affect your body and prevent adverse drug reactions.
Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry