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Side Effects of Celecoxib (Celebrex)


Description: Celebrex (sometimes referred to by its generic name celecoxib), belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). Celebrex is used for the respite of symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Serious Side Effects

Critical adverse reactions according to the Celebrex label reported by the FDA involve serious gastrointestinal toxicity such as bleeding, ulceration, and perforation of the stomach, small intestine or large intestine

Common Side Effects

Most commonly reported adverse reactions in clinical trials according to the Celebrex label include:

  • Abdominal pain
  • Indigestion
  • Loose motion (diarrhea)
  • Heartburn (dyspepsia)
  • Flatulence
  • Swelling of hand and feet (peripheral edema)
  • Dizziness
  • Pharyngitis
  • Rhinitis
  • Less Common Side Effects

    These reactions have been reported at low frequencies according to the Celebrex label:
    Constipation, diverticulitis, dysphagia, eructation, esophagitis, gastritis, gastroenteritis, gastroesophageal reflux, hemorrhoids, hiatal hernia, melena, stomatitis, tooth disorder, vomiting, Cardiovascular Aggravated hypertension, dry mouth, glaucoma, tenesmus General Allergy aggravated, allergic reaction, asthenia, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes, influenza-like symptoms, pain, peripheral pain Resistance Mechanism Herpes simplex, herpes zoster, infection bacterial, infection Disorders fungal, infection soft tissue, infection viral, moniliasis, moniliasis genital, otitis media Central, peripheral Leg cramps, hypertonia, hypoesthesia, migraine, neuralgia, neuropathy, nervous system paresthesia, vertigo, Female reproductive Breast fibroadenosis

    Understand Your Risk for Side Effects with the Rxight® Pharmacogenetic Testing Program

    Pharmacogenetic testing with Rxight® analyzes how you metabolize Celebrex and other NSAIDs, along with hundreds of other prescription and over-the-counter medications, to help determine if you are likely to suffer side effects so your prescriber can adjust dosing or find an alternative accordingly.
    Rxight® PGX testing specifically provides patients with an analysis of 18 genes involved in drug metabolism in one convenient test panel, along with a detailed analysis of their metabolism of hundreds of prescription and over-the-counter medication across 50 pharmacological classes, which will be reviewed with you by a pharmacist trained in pharmacogenetic testing.

    How Does Pharmacogenetic Testing Work?

    Many people have normal activity of liver enzymes responsible for processing Celebrex, and thus experience therapeutic value with minimal side effects on standard doses. However, other people are less fortunate, and may have differences in one or more of these liver enzymes as determined by their unique genetic encoding for those enzymes, leading to dangerously high levels, which can lead to serious adverse reactions. Such patients are often referred to as “slow metabolizers.” Others process the medication more quickly than normal, and these are known as “rapid metabolizers.” Such patients need higher doses than are normally prescribed in order to effectively manage their symptoms. With your PGx testing results, your prescriber can tailor your medication plan to your unique genetically modulated metabolism.

    Contributors to this Article:
    Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

    Read more about Rxight® drug sensitivity testing