Description: Rosuvastatin, commonly known by its trade name Crestor, is a commonly used statin. It is used in the prevention of cardiovascular disease – often in
combination with weight loss and dietary restrictions.
Serious Side Effects of Crestor
According to the Crestor label as reported by the FDA (Feb 2010), severe adverse reactions to statins including Crestor include: skeletal muscle effects including statin myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria; proteinuria and microscopic hematuria, and liver enzyme abnormalities.
Common Crestor Side Effects
Common adverse reactions to Crestor according to the Crestor label as reported by the FDA (Feb 2010), include:
Less Common Side Effects of Crestor
Rare reactions include:
(Crestor label as reported by the FDA, Feb 2010).
Understand Your Risks with the Rxight® Genetic Test
Most patients experience no side effects when taking rosuvastatin although some might experience multiple adverse reactions. This variability between patients might be the result of genetic differences between patients. For instance, individual differences (called “polymorphisms”) in the transporter channel SLCO1B1 can cause differences in uptake of rosuvastatin. Increased blood concentration of the drug might increase the probability of a patient developing side effects as well. The drug is metabolized by the cytochrome P450 superfamily of enzymes, namely isoenzymes CYP2C9 and CYP3A4. Mutations in these genes may cause poor metabolism of the drug and an increased chance of developing side effects. MD Labs pharmacogenetic testing can examine these genes and find if you can handle the medication appropriately.
How Does Pharmacogenetic Testing Work?
MD Labs provides the most comprehensive genetic testing for drug sensitivity available – Rxight ® Pharmacogenetics, which is grounded in the sequencing of 18 genes (including SLCO1B1 and CYP enzymes) and tests over 60 alleles to establish how patients react to more than 200 clinically relevant medications (including Crestor/rosuvastatin). This can aid prescribers’ decision making when prescribing the drug. For instance, a physician may lower the dose in a patient with a mutation in SLCO1B1, potentially reducing the risk of developing side effects, or find an alternative – preferably before treatment begins.
Contributors to this Article:
Michael Sapko, MD, PhD; Deborah Kallick, PhD, Medicinal Chemistry
Read more about Rxight® pharmacogenetic testing