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Side Effects of Azilsartan Kamedoxomil (Edari)

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Side Effects of Azilsartan (Edarbi)

Azilsartan, available under the brand name of Edarbi, is in a class of medications called angiotensin II receptor antagonists. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently. This results in lower blood pressure. Azilsartan is also used to treat high blood pressure (hypertension) in adults alone or in combination with other medications. 

Common Side Effects of Azilsartan (Edarbi)

The Edarbi label published by the FDA reports commonly reported adverse effects with azilsartan:

  • Loose motion
  • Nausea
  • Fatigue/lethargy
  • Muscle spasms
  • Dizziness or lightheadedness (which could be posture related)
  • Cough

Drug Interactions

The FDA warns to not use Edarbi if you are pregnant. Edarbi can cause harm or death to your unborn baby. It is not known if Edarbi passes into your breast milk. You and your doctor should decide if you will take azilsartan or breastfeed. You should not do both. Talk with your doctor about the best way to feed your baby if you take Edarbi.

 

Before you take Edarbi, tell your doctor if you have been told that you have abnormal body salt (electrolytes) levels in your blood such as low levels of potassium or magnesium in your blood or if you are on a low-salt diet.

 

Inform your doctor if you take other medicines used to treat your high blood pressure or heart problems, or NSAIDs (non steroidal anti-inflammatory drugs), such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam. Discuss with your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Your doctor may switch you to a different medicine to treat your high blood pressure.

 

Low blood pressure (hypotension) and dizziness can occur more if you also take water pills (diuretics), take other medicines that affect your blood pressure, are ill with vomiting or diarrhea, or do not drink enough fluids. If you have diabetes, prevent using Azilsartan together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

(Label on Edarbi reported by the FDA).

When to Contact Your Doctor

Immediately contact your healthcare provider if you have painful or difficult urination, little or no urinating, feeling tired or short of breath, a light-headed feeling, like you might pass out, or swelling in your feet or ankles.

About Pharmacogenetic Testing

Edarbi is primarily metabolized in the body by CYP2C9. Genetic variations in CYP2C9 do exist in some individuals, which might make them susceptible to the side effects. Theoretically, pharmacogenetic testing to identify such individuals could become a tool to optimize azilsartan therapy.

 

If a patient has a given allele in the CYP2C9 that metabolizes azilsartan, pharmacogenetic testing allows a clinician to prescribe a different drug or modify the starting dose. This can reduce side effects associated with azilsartan.

Know Your Risk of Side Effects with the Rxight® Genetic Test

With Rxight®, you can find out what genetic variations you may have. This will help in guiding your doctor and pharmacist to create a personalized treatment fitting your genes. With advanced technology, Rxight tests 60 alleles on 21 genes to examine how a patient metabolizes over 200 medications including Edarbi.

 

The Rxight® test is accurate, prompt, easy to understand, and reliable making it a guide for pharmacists to create a treatment plan that prevents adverse drug reactions and allowing patients to get on the right medications sooner.

 

Call us to learn more about Rxight® pharmacogenetic testing, at 1-888-888-1932 or email us at support@Rxight.com.

 

Contributors to the Article:
Michael Sapko, MD, PhD; Deborah Kalllick, PhD, Medicinal Chemistry

Read more about Rxight® Genetic Health Testing