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Side Effects of Prasugrel (Effient)


Side Effects of Prasugrel (Effient)

Prasugrel, available as the brand Effient, is an antiplatelet medication. The drug is primarily used to prevent thrombosis (blood clots). Effient treatment is for patients with acute coronary syndrome.

Common Side Effects

According to the FDA, Effient’s common side effects are hematologic (blood related) .


  • Bleeding
  • Symptomatic intracranial hemorrhage (extravascular bleed in the brain)
  • Thrombotic thrombocytopenic purpura (excessive clotting in small blood vessels)
  • Anemia (low red blood cell count)
  • Leukopenia (low white blood cell count)
  • Hypertension (high blood pressure)
  • Hypotension (low blood pressure)
  • Atrial fibrillation (a fast or irregular abnormal heartbeat)
  • Peripheral edema (swelling in legs and arms)
  • Bradycardia (low heart rate)


Other common side effects are dyspnea (difficult breathing), cough, back pain, chest pain, joint pain, rash, fatigue, fever, nausea, diarrhea, hypercholesterolemia (high cholesterol), headache, and dizziness (Effient label as listed by the FDA).

About Pharmacogenetic Testing

Effient is metabolized by the cytochrome P450 superfamily of enzymes (these enzymes metabolize some 75% of all clinically relevant drugs). The drug is metabolized by isoenzymes CYP3A4 and CYP2B6. It is possible that some polymorphisms may cause poor metabolism of the drug, resulting in increased blood concentrations and a higher chance of developing side effects such as excessive bleeding.

Know Your Risk with the Rxight® Genetic Test

Identifying these polymorphisms can aid in clinical decision. The Rxight® test sequences 18 genes, including CYP3A4 and CYP2B6 to establish how a patient is likely to react to more than 200 clinically relevant medications, including Effient.


Contact us to learn more about Rxight® at 1-888-888-1932 or email us at support@Rxight.com.


Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® : What is Pharmacogenetics?