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Side Effects of Piroxicam (Feldene)


Side Effects of Piroxicam (Feldene)

Piroxicam, known as the brand Feldene, is a nonsteroidal anti-inflammatory (NSAID) drug. NSAIDs work by reducing substances in the body that cause pain and inflammation. Feldene is used to treat pain or inflammation caused by osteoarthritis or rheumatoid arthritis.

Before Taking Feldene

The FDA warns to not use Feldene during the last 3 months of pregnancy because it can harm the unborn baby. You should not breast-feed while taking Feldene because Feldene can excrete into breast milk and harm a nursing baby.


Avoid drinking alcohol because it has a higher risk of stomach bleeding. The elderly may also have a higher chance of experiencing the side effects of Feldene, specifically stomach bleeding and kidney problems.


Do not use Feldene before or after heart bypass surgery (coronary artery bypass graft, or CABG). You should also not use Feldene if you have a known allergy to it, have ever had an asthma attack or a severe allergic reaction after taking aspirin or an NSAID, and have active stomach or bowel bleeding.

Serious Side Effects

The FDA advises Feldene can increase the risk of fatal heart attack or stroke, especially if used long term or taken in high doses, or if you have heart disease.


If there are signs of an allergic reaction such as rash, hives, itching, trouble breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue, or signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath), receive medical attention immediately.


In addition, stop your Feldene treatment and contact your healthcare provider if any of the following symptoms occur:


  • Blood in the vomit or stool
  • Dark and/or tarry stools
  • Nausea
  • Fatigue or lethargy (lack of energy)
  • Pruritus (severe itching on the skin
  • Jaundice (yellowing of the skin or whites of the eyes)
  • Right upper quadrant tenderness
  • Flu-like symptoms or fever
  • Rash and blisters
  • Kidney problems (little to no urination, painful or difficult urination)
  • Swelling in feet or ankles


(Feldene label reported by the FDA).

Common Side Effects

The common side effects of Feldene are abnormal liver function problems, urination problems, upset stomach, heartburn, loss of appetite, stomach pain, nausea, vomiting, gas, diarrhea, constipation, dizziness, headache, itching, rash, and ringing in your ears (Feldene label reported by the FDA).

Drug Interactions

The Feldene label reported by the FDA states that certain medicines may interact with Feldene. It is important to inform your healthcare provider if you are taking the following medicines: anticoagulants specifically Warfarin, aspirin, clopidogrel, corticosteroids (prednisone), heparin and other blood thinners, such as dalteparin, or selective serotonin reuptake inhibitors (SSRIs) like fluoxetine (Prozac) because the risk of bleeding may be increased.


Feldene may increase the following medicines’ side effects: lithium, metformin, methotrexate, aspirin or oral NSAIDs, or quinolones (ciprofloxacin).


The effectiveness of angiotensin-converting enzyme (ACE) inhibitors, such as enalapril or diuretics (furosemide or hydrochlorothiazide) may be decreased by Feldene.

About Pharmacogenetic Testing

Variations in gene encoding drug metabolizing enzyme, CYP2C9, might play a significant role in the pain relieving and side effect NSAIDs, including piroxicam. Due to this, individuals with low CYP2C9 activity exhibit low elimination and reduced analgesic efficacy. Hence, pharmacogenetic testing to detect such variations can potentially help your healthcare provider to optimize this drug for you.

Know Your Risk with the Rxight® Genetic Test

MD Labs developed Rxight® with state-of-the-art technology that analyzes the genetic variants that affect the enzymes responsible for metabolizing drugs and show how your body processes them. Your results from Rxight® helps you healthcare provider understand if you are more likely to experience side effects from a medication or if it is ineffective.


To know more about Rxight®, call us at 1-888-888-1932 or email us at support@Rxight.com.


Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® Drug Sensitivity Testing