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Side Effects of Ketorolac (Toradol, Sprix)


Ketorolac (Toradol) Side Effects

Ketorolac, available under the brand Toradol, is a pain relieving and anti-inflammatory medication that reduces the chemicals that cause pain and swelling. It is used for short-term for pain relief after surgery, after labor or after injury causing muscle or joint pain. It is available in oral or injection form,Toradol, or as nasal spray, Sprix.

Serious Side Effects

According to the Toradol label reported by the FDA, serious side effects include: peptic ulcers, gastrointestinal bleeding, perforation of the stomach or intestines, which can be fatal. Also, myocardial infarction and stroke can occur. Toradol can also negatively affect those in labor or those with renal risks.

Common Side Effects

The most common side effects associated with Toradol are: constipation, diarrhea, dizziness, indigestion, mild stomach pain or upset, drowsiness, headache, nausea, stomach fullness, sweating, and vomiting (Toradol label reported by the FDA).


The FDA also lists the less than common side effects:


  • Fever
  • Infections
  • Congestive heart failure
  • Palpitations (rapid or irregular heartbeats)
  • Tachycardia (abnormally fast heartbeats)
  • Alopecia (patchy hair loss)
  • Photosensitivity
  • Anorexia
  • Dry mouth
  • Eructation (belching)
  • Esophagitis (esophagus inflammation)
  • Excessive thirst
  • Gastritis (stomach inflammation)
  • Glossitis (inflammation of the tongue)
  • Hematemesis (vomiting blood)


Other less than common side effects are hepatitis (liver inflammation), increased appetite, jaundice (yellowing of the skin), melena (feces containing blood), rectal bleeding, ecchymosis (reddish or bluish discoloration of the skin), eosinophilia (building up of white blood cells), epistaxis (nose bleeding), and leukopenia (decreased number of white cells).

Drug Interactions

Toradol may cause drowsiness or dizziness. Toradol side effects will be worse if taken with alcohol or certain medicines. Do not drive or perform other possibly unsafe tasks unless sure about the effects. Toradol may cause harm to the unborn baby so it should be avoided during the last 3 months of pregnancy and breast-feeding.

About Pharmacogenetic Testing

In 2009, there were nearly 4.6 million drug-related emergency department visits nationwide; half of those came from adverse reactions to prescription drugs. This is due to genetic variations with people. Pharmacogenetic testing examines these differences and relaying that information to doctors and physicians. As a result, potential adverse reactions can be avoided and ensuring safer medication usage.

Know Your Risks with the Rxight® Genetic Test

Toradol is one of the medications tested by the Rxight® pharmacogenetic panel. Genetic testing with Rxight® specifically analyzes genes, which encode for the metabolism of over 200 prescription and over-the-counter (OTC) medications over a wide range of therapeutic classes.


For more information on Toradol’s adverse reactions or about Rxight® pharmacogenetic testing, contact us at 1-888-888-1932 or at support@Rxight.com.


Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® : What Is PGx Testing?