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Side Effects of Fluvastatin (Lescol)


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Side Effects of Fluvastatin (Lescol or Lescol-XL)

Fluvastatin, available under the brands Lescol or Lescol-XL is an HMG-CoA reductase inhibitor, also known as a statin that lowers the “bad” (low-density lipoprotein) cholesterol and triglycerides level in the blood. In addition, it can increase “good” (high-density lipoprotein) cholesterol as well.


Lescol is given to people whose cholesterol level does not come down enough with exercise and a low-fat diet alone. In addition, Lescol is for heart disease (coronary artery disease) treatment in patients. Lescol helps lower the chances of heart problems which prevents the requirement of procedures to help restore blood flow to the heart and slow the buildup of excessive cholesterol in the arteries of the heart.

Warnings Before Taking Lescol

Before taking Lescol, tell your health care providers if you have muscle aches or weakness, drink more than 2 glasses of alcohol daily, have diabetes, have a thyroid problem or have kidney problems.


Some medicines, including prescription and non-prescription medicines, vitamins and herbal supplements should not be taken with Lescol because they can interact and causing serious side effects. Discuss with your health care provider about all the medicines you take, especially if you take medicines for your immune system, cholesterol, infections, heart failure, seizures, diabetes, heartburn or stomach ulcers (Lescol label reported by the FDA).


Fluvastatin should not be taken by pregnant women or women who think they may be pregnant, or are planning to become pregnant, women who are breast-feeding as Lescol can pass into breast milk and thereby may harm baby, individuals with liver problems and individuals who have known allergies to Lescol.

Serious Side Effects

According to the FDA, when taking Lescol, some patients may develop serious side effects.


Call your health care provider immediately if you experience unexplained muscle pain, tenderness, or weakness accompanied with a fever. These symptoms could be early signs of a rare muscle problem that leads to serious kidney problems. The risk of muscle problems is greater in elderly people or patients with history of thyroid or kidney problems.


There is an increased risk of muscle problems if other medicines are taken with Lescol. If your muscle problems that do not go away even after stopping Lescol treatment, inform your health care provider. Tests will be conducted to diagnose the cause of your muscle problems. Your doctor should do blood tests to check your liver before you start taking Lescol, and if you have symptoms of liver problems while you take it. Contact your health care provider right away if you have the following symptoms of liver problems:


  • Tiredness or weakness
  • Loss of appetite
  • Upper belly pain
  • Dark amber colored urine
  • Yellowing of your skin or the whites of your eye

Common Side Effects

The most common side effects of Lescol are headache, upset stomach and stomach pain, diarrhea, flu-like symptoms, muscle pain, sinus infection, tiredness, or trouble sleeping. These side effects are usually mild and don’t require any intervention. Additional side effects are memory loss and confusion (Lescol label reported by the FDA).

About Pharmacogenetic Testing

The metabolism of Lescol takes place in the liver. The gene polymorphism in cytochrome 450 that has major role in the break down of Lescol is CYP2C9. In addition, CYP2C8 and CYP3A4 are less involved.

Know Your Risk with the Rxight® Genetic Test

The Rxight® pharmacogenetic test from MD Labs examines your genes to analyze how they metabolize over 200 prescription and over-the-counter (OTC) medications. The test is done with a simple cheek swab that collects your entire DNA. Your results from the Rxight® test demonstrate what medications are effective, ineffective, and dangerous to you. With this, your doctor will be able to design the Rxight® plan for successful present and future treatment plans that prevent severe drug reactions.


For more information on the Rxight® test, give us a call at 1-888-888-1932 or send us an email at support@Rxight.com.


Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® : What is Pharmacogenetics?