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Side Effects of Levorphanol (Levo Dromoran)


Side Effects of Levorphanol (Levo Dromoran)

Levorphanol, also known as the brand Levo Dromoran is an opioid. Levo Dromoran works by acting in nerves in the brain and spinal cord to decrease the feeling of pain. It may also be used before surgery for pain management and for other conditions.

Warnings Before Taking Levo Dromoran

The FDA advises to not use Levo Dromoran if you have allergies to levorphanol or similar medicines (morphine), taking a monoamine oxidase (MAO) inhibitor, such as phenelzine, a narcotic agonist/antagonist medicine (pentazocine), sodium oxybate, are having certain types of surgery, specifically biliary surgery, have severe asthma, or diarrhea caused by antibiotic use.


Discuss with your healthcare provider if you have any medical conditions, are pregnant or breast-feeding, taking any prescription or nonprescription medicine, herbal preparation, dietary supplement, have allergies to medicines, foods, or other substances, or have a history of prostate problems, seizures, heart problems, kidney complications.


You should inform your doctor about other conditions:


  • An underactive thyroid
  • Liver disease
  • Severe inflammatory bowel disease
  • A head injury or increased pressure within the head
  • Asthma
  • A brain tumor
  • Trouble urinating
  • Low blood pressure
  • A history of mental or mood problems or suicidal thoughts
  • Will be having surgery on the stomach, intestines, liver, or gallbladder
  • Consumption of large amounts of alcohol or a history of substance abuse or dependence


Levo Dromoran can cause drowsiness, dizziness, fainting or lightheadedness. It is important to avoid driving, operating machinery, or doing anything else that could be dangerous until you are sure you can handle the effects. Hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning.


While taking Levo Dromoran , avoid drinking alcohol or taking other medications including sedatives or tranquilizers because they cause drowsiness. Levo Dromoran should be used with caution in the elderly because they may be more sensitive to its effects.

Serious Side Effects

The FDA reports severe side effects, such as profound drowsiness, loss of consciousness, dangerously low blood pressure, or trouble breathing may occur. These effects can be fatal, depending upon your body’s genetically determined ability to process narcotics.

Common Side Effects

Most common side effects associated with Levo Dromoran are:


  • Constipation
  • Dizziness
  • Altered mood and thoughts
  • Drowsiness
  • Flushing
  • Nausea
  • Reaction or pain at the injection site
  • Vomiting


(Levo Dromoran reported by the FDA).

About Pharmacogenetic Testing

Pharmacogenetics has established that individuals have variations in their genetic variations in how medications are metabolized. The study of pharmacogenetics came from the sequencing of the human genome and determines what drugs cause adverse reactions and which are ineffective.

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Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® Individualized Medicine