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Side Effects of Fluvoxamine (Luvox)


Side Effects of Fluvoxamine (Luvox)

Fluvoxamine, commonly known as the brand Luvox, is an anti-depressant in the selective serotonin reuptake inhibitor (SSRI) class. It is most often used for obsessive-compulsive disorder (OCD) but may be used for other mood disorders. Luvox helps decrease unwanted or persistent thoughts or obsessions and urges to perform repeated tasks such as hand washing, counting or checking that interrupt daily living. This drug retains its therapeutic efficacy for at least a year and has been found to possess some analgesic properties in line with other SSRIs.


Luvox may also be used to treat major depressive disorder and anxiety disorders such a PTSD (post-traumatic stress disorder) or panic disorder. It is also used to treat social anxiety disorder. This medication works by increasing the natural balance of serotonin in the brain.

FDA Black Box Warning

The FDA added a black box warning that warns of increased risk of suicidal thinking in young adults and children. Young adults and children taking this medication should be watched carefully during drug therapy.

Common Side Effects

The FDA reports that gastrointestinal side effects are more common with Luvox than with other SSRIs.


Other common side effects include:


  • Nausea
  • Weight loss
  • Vomiting
  • Anxiety
  • Nervousness
  • Agitation
  • Tremor
  • Insomnia
  • Dizziness
  • Tachycardia (abnormally fast heart rate)
  • Palpitations (irregular heart beats)
  • Abdominal pain
  • Indigestion
  • Excess sweating
  • Weakness
  • Sexual dysfunction
  • Malaises (discomfort)

About Pharmacogenetic Testing

According to the FDA, Luvox is mainly metabolized in the liver and is shown to inhibit other gene polymorphisms in cytochrome 450 involved in other common medications. These include CYP1A2 (Warfarin, Theophylline, Propranolol, Tizanidine), CYP2C9 (Warfarin), CYP3A4 (Alprazolam), and CYP2C19 (Omeprazole). In vitro studies have demonstrated that Luvox is a weak inhibitor of CYP2D6.

Know Your Risk for the Rxight® Genetic Test

Genetic variations within individuals affect how enzymes in the body metabolize medications. The Rxight® test identifies these genetic variations and their role in how your body breaks down over 200 prescription and over-the-counter (OTC) medications. Based on your results from the Right® test, your health care provider will be able to understand how your genes metabolize medications. Rxight® helps your health care provider in designing an individualized and successful treatment plan with optimal dosages and stopping adverse drug reactions.


Call us to learn more about Rxight® genetic testing, at 1-888-888-1932 or email us at support@Rxight.com.


Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

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