Side Effects of Glyburide (DiaBeta, Micronase, Glynase)
Glyburide, available under the brand Micronase, is an antidiabetic drug part of the sulfonylurea class. It is used to treat type II diabetes to stimulate the beta cells (cells responsible for producing, storing, and releasing insulin) of the pancreas to secrete more insulin. It only works if there are some remaining beta cells in the pancreas. Once insulin is secreted, blood sugar is lowered, helping the patient to sustain a normal range of blood sugar levels. The treatment is normally used with diet and exercise, to help the patient lead a more normal lifestyle even with a diagnosis of type II diabetes. Micronase is often used with an additional diabetes drug, metformin. The exact mechanisms are not known, but the two drugs together exert a synergistic effect on the blood glucose levels.
Warnings Before Micronase Treatment
The FDA recommends precautions before taking Micronase. While taking Micronase you should limit or avoid alcohol. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual dysfunction issues.
Micronase Common Side Effects
Common side effects of Micronase are:
- Weight gain
- Stomach fullness
In addition, the FDA advises to inform your doctor right away if you have:
- Signs of infection
- Easy bleeding or bruising
- Stomach pain
- Dark urine
- Jaundice (yellowing of the eyes or skin)
- Unusual weakness
- Swelling of the hands or feet, or seizures
Some side effects of this and other medications may be lessened by altering your dose or in some cases changing the medication entirely. This trial and error approach to prescribing medications has long been used and led to the suspicion that many people may not have the ‘standard’ drug processing or drug metabolism genes. Once the human genome was sequenced, genome wide association studies showed people have variations in their drug metabolism genes. Since genes encode proteins (or enzymes), variation in the gene for any particular drug results in variation in the actual enzyme that does the drug processing work. This is why different people have different responses to drugs. Pharmacogenetics research has shown this to be the case.
Know Your Risk with the Rxight® Genetic Test
MD Labs developed a state-of-the-art pharmacogenetics test called Rxight® that uses an advanced platform to test most of your drug metabolism genes. All that is required is a cheek swab from a participating pharmacy. Once you get this test, your physician can determine what doses are appropriate for a given medicine, potentially reducing drug side effects for the lifetime of your association with that physician. It’s also possible you may learn that some drugs should not be prescribed for you. This individualized, personal medicine may be a better way to receive medical care. Ask your physician today to prescribe the Rxight® pharmacogenetics test from MD Labs. It’s time to bring precision medicine to your individual care and treatment.
Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry
Read more about Rxight® : What is Pharmacogenetics?