Side Effects of Meloxicam (Mobic) Side Effects
Meloxicam, also known as the brand Mobic, is a nonsteroidal anti-inflammatory drug (NSAID). Mobic’s primary functions are to reduce hormones that cause inflammation and pain in the body caused by rheumatoid arthritis and osteoarthritis. The medication is also used in the treatment of juvenile rheumatoid arthritis.
Serious Side Effects
Mobic, like other NSAIDs, can cause serious side effects, according to the FDA. These include:
- Increased risk of fatal heart attack or stroke (especially if used for a long duration or taken in high doses)
- Heart disease
- Higher risk of bleeding, ulcers, and tears (perforation) of the esophagus, stomach and intestines does not matter of duration of treatment, can occur without warning symptoms, and may be fatal)
Other serious life-threatening side effects include exfoliative dermatitis (redness and peeling of large skin areas), Stevens-Johnson syndrome (rare and serious disorder of the blistering and peeling of the skin and mucous membranes), and toxic epidermal necrolysis (severe, life-threatening disorder of the blistering and peeling of the skin and mucous membranes) that may result in hospitalization and even death.
Common Side Effects
Common Mobic side effects include: upset stomach, nausea, vomiting, heartburn, diarrhea, constipation, gas, dizziness, cold symptoms, and flu symptoms (Mobic label reported by the FDA).
When to Contact Your Doctor
The FDA recommends to stop using Mobic and seek emergency help if you have any of the following symptoms: any symptoms of a heart attack or stroke, chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, changes in vision, shortness of breath, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, swelling, rapid weight gain, liver problems, itching, fatigue, loss of appetite, and kidney problems, such as not urinating, dark urine, or painful urination.
Other symptoms are:
- Jaundice (yellowing of the skin or eyes)
- Swelling in your feet, ankles, face, tongue, or throat
- low red blood cells (anemia)
- rapid heart rate
- Trouble concentrating
- Severe skin reaction, skin rashes, or skin pain followed by a red or purple skin rash that spreads in the face or upper body and causes blistering
- Sore throat
- Burning in eyes
- Signs of an anaphylactic reaction (difficulty breathing)
The chance of getting an ulcer or bleeding is higher if you are age 60 or older, have had stomach ulcers, bleeding problems, have three or more alcoholic drinks every day while using this product or take the medication for a longer time than directed. Some medications, such as anticoagulants (Warfarin), aspirin, corticosteroids (prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs), may cause you to bruise or bleed easily if you take it with Mobic.
About Pharmacogenetic Testing
Mobic is metabolized in the liver according to PharmGKB. Mobic is metabolized in the cytochrome P450 (CYP450) iso enzymes. The polymorphism primarily involved is CYP2C19 with CYP3A4 having a minor part. The other major metabolites that break down Mobic are 5′-hydroxymethyl meloxicam which metabolites further into 5′-carboxy meloxicam.
Know Your Risk with the Rxight® Genetic Test
To avoid complications from Mobic, Rxight® genetic testing can be an invaluable tool. It is a quick, simple solution that gives doctors the ability to see how you will react to a medication before it is used, based on your unique genetics. Based on this pharmacogenetic analysis, you and your prescriber can determine a safe dose or alternative medication.
Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry
Read more about Rxight® : What is Pharmacogenetics?