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Side Effects of Ketoprofen (Orudis, Actron, Oruvail, Nexcede)

FIND A PHARMACIST WHO OFFERS GENETIC TESTING FOR NSAIDs

Side Effects of Ketoprofen (Orudis)

Ketoprofen, available under the brands Orudis and Oruvail, is a pain relieving and anti-inflammatory medication (NSAID) which works by reducing substances in the body that cause pain and inflammation. Orudis is used to treat mild to moderate pain or inflammation caused by arthritis or menstrual pain.

Before Orudis Treatment

Consult with your healthcare provider if you have heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke, if you have heart attack, stroke, or blood clot history, a history of stomach ulcers or bleeding, asthma, liver, kidney disease, or fluid retention (Orudis label as reported by the FDA).

 

Taking Orudis during the last 3 months of pregnancy may harm the unborn baby. Do not use this medicine without consulting your healthcare provider if you are pregnant or breast-feeding. Ketoprofen may cause sleepiness, lack of concentration, dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Avoid driving or performing other possibly unsafe tasks until you are sure about Orudis’ effects on you.

 

The elderly may be more prone to Orudis’ risks especially if they have a history of stomach bleeding and kidney problems.

Serious Side Effects

Orudis, like other NSAIDs, can cause serious side effects, including increased risk of fatal heart attack or stroke, especially if used for long term or taken in high doses. If you have heart disease, there is an increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach)or stomach and intestines.

 

The FDA advises there is an increased risk of bleeding If you:

 

  • Are 60 years or older
  • Have a history of stomach ulcers or bleeding problems
  • Take an anticoagulant (blood thinner) or steroid drugs, other drugs containing prescription or nonprescription NSAIDs
  • Have three or more alcoholic drinks every day while using Orudis
  • Take Orudis longer than needed

Common Side Effects

The FDA lists the common Orudis side effects: constipation, diarrhea, dizziness, drowsiness, gas, headache, heartburn, nausea, stomach upset. Orudis should not be used if you are allergic to it, have ever had an asthma attack or severe allergic reaction (severe rash, hives, trouble breathing, growths in the nose, dizziness) after taking aspirin or an NSAID, or just before or after heart bypass surgery (coronary artery bypass graft or CABG).

When to Contact Your Doctor

Stop using ketoprofen and immediately contact your healthcare provider if experience:

 

  • Changes in your vision
  • Shortness of breath
  • Swelling
  • Rapid weight gain
  • Signs of any skin rash
  • Signs of stomach bleeding
  • Bloody or tarry stools
  • Coughing up blood or vomit that looks like coffee grounds
  • Liver problems
  • Nausea
  • Upper stomach paini
  • Itching
  • Tired feeling
  • Other flu-like symtpoms

 

Inform your doctor if you also experience loss of appetite, dark urine, jaundice (yellowing of the skin or eyes),kidney problems, little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath, severe skin reaction, fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash resulting in blistering and peeling (Orudis label reported by the FDA).

Drug Interactions

Certain medicines may interact with Orudis. Tell your health care provider if you are taking any other medicines, such as: anticoagulants (Warfarin), aspirin, corticosteroids (prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs), like fluoxetine. There is an increased risk of stomach bleeding if Orudis is taken with these medications.

 

Orudis’ adverse effects may be increased with probenecid. The side effects of cyclosporine, lithium, methotrexate, quinolones (iprofloxacin), or sulfonylureas (glipizide) because the risk of their side effects may occur more because of Orudis. The effectiveness of angiotensin-converting enzyme or ACE inhibitors (enalapril) or diuretics (furosemide or hydrochlorothiazide) because the effectiveness may be decreased by Orudis.

About Pharmacogenetic Testing

Pharmacogenetics research has revealed that individuals have variations in genes. These genes metabolize medicines. Some individuals may experience the serious side effects of medications, some may not experience them at all, and others may find the medication ineffective.

Know Your Risk with the Rxight® Genetic Test

The Rxight® test analyzes 18 genes on 60 alleles to see how the body responds and metabolizes drugs. The Rxight® genetic test gives patients and pharmacists valuable genetic knowledge. With this genetic information, a pharmacist will be able to design the best treatment plan that is tailored to fit a patient’s genetic profile.

 

For more information on the Rxight® genetic test, contact by calling 1-888-888-1932 or emailing support@Rxight.com.

 

Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® Genetic Testing Labs