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Side Effects of Ezogabine (Potiga)


Side Effects of Ezogabine (Retigabine, Potiga)

Ezogabine, sold under the brand Potiga, is a novel antiepileptic drug, different from antiepileptic drugs on the market. Potiga is a potassium channel agent that is thought to enhance trans membrane potassium currents mediated by the potassium family of ion channels. This medication does not act on any cardiac related targets, potentially avoiding any cardiac side effects.


Potiga is prescribed for partial-onset seizures in adult patients with refractory epilepsy (uncontrolled or drug resistant epilepsy). Numerous studies have indicated that Potiga is effective in a broad spectrum of epilepsy and seizure models. Be sure to tell your physician about every drug you are taking, including over the counter products and herbals as this medication interacts with a number of drugs on the market.

Serious Side Effects

The FDA lists the serious side effects of Potiga:


  • Withdrawal seizures
  • Suicidal behavior and ideation
  • QT interval changes (a lengthened one may be a risk factor for sudden death)
  • Urinary retention
  • Hallucinations
  • Sleepiness
  • Confusion or behavioral changes

Common Side Effects

Common side effects include drowsiness, dizziness, confusion, tremor, blurred vision, fatigue, ataxia (loss of control of body movements), and skin discoloration (Potiga label reported by the FDA).

About Pharmacogenetic Testing

Some side effects may be lessened by your physician’s knowledge of your pharmacogenetics prior to prescribing Potiga and other medications. Pharmacogenetics research has shown that there is wide variation in the genes that encode the enzymes metabolize most medications on the market.


Gene variability means that you may not be able to process or metabolize the medication as expected or you may not be able to take the medication safely. That is the benefit of pharmacogenetics: informing your physician what medications you can take safely and what medications need different dosing or a different medicine entirely.

Know Your Risk with the Rxight® Genetic Test

Ask your physician today to prescribe the Rxight® pharmacogenetics test from MD Labs. This test should be taken before taking any new medicine to determine your ability to process over 200 medications and over-the-counter (OTC) medications for potential increased safety and tolerability. Get started on the Rxight® test that helps your physician deliver precision medicine to you and prevent adverse effects. It’s the Rxight® thing to do.


Want more information on how to get started with Rxight®? Give us a call at 1-888-888-1932 or send us an email at support@Rxight.com.


Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry