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Side Effects of Dabigatran Etexilate (Pradaxa)

FIND A PHARMACIST WHO OFFERS GENETIC TESTING FOR Direct Thrombin Inhibitors

Description: Pradaxa is used to reduce the risk of stroke and blood clots in people who have a medical condition called atrial fibrillation (AFib). Atrial fibrillation is an irregular and often very fast heart rate. This may cause symptoms like heart palpitations, fatigue, and shortness of breath. by reducing the risk of blood clot forming in the heart and traveling to the brain, where it can cause a stroke. Pradaxa is also used to treat blood clots in the veins of your legs or lungs and reduce the risk of them occurring again. It is also sometimes prescribed for patients who have had knee or hip replacement to minimize bleeding.

Serious Side Effects of Pradaxa

The medication can cause fatal bleeding, risk of developing an epidural or spinal hematoma which can result in long-term or permanent paralysis according to the Pradaxa label Call your doctor right away if any of these symptoms occur:

  • Unusual bruising (bruises that appear without known cause or that get bigger)
  • Pink or brown urine
  • Red or black, tarry stools
  • Coughing up blood
  • Vomiting blood

Common Side Effects of Pradaxa

According to the Pradaxa label, commonly reported side effects include: upset stomach, burning stomach pain or indigestion. Also, dyspepsia and gastritis-like symptoms (including GERD, esophagitis, erosive gastritis, gastric hemorrhage, hemorrhagic gastritis, hemorrhagic erosive gastritis, and gastrointestinal ulcer) were reported as well.

Less Common Side Effects of Pradaxa

These reactions were reported with a low frequency; less than 1% according to the Pradaxa label:

  • Drug hypersensitivity (including urticaria, rash, and pruritus)
  • Allergic edema
  • Anaphylactic reaction
  • anaphylactic shock

Understand Your Risks with the Rxight® PGx Testing Program

For optimal safety in dosing and frequency if you have been prescribed Pradaxa, ask your physician to first prescribe Rxight®, the most comprehensive pharmacogenetic test available from MD Labs that is available from your pharmacist through a simple cheek swab. This test will tell your provider what genetic variants you have that may require adjustment of dose or frequency of your medicine. Recent advances in medicine have shown that genetic variability in genes that are responsible for making the enzymes that metabolize drugs can alter the way a patient responds to medications.

How Does Pharmacogenetic Testing Work?

Rxight® genetic testing will tell your provider about your ability to metabolize over 200 prescription and over-the-counter medications. This area of study is called pharmacogenetics and is instrumental in bringing precision or individualized medicine to you, the patient. By elucidating your specific genetic variation in the genes that metabolize medicines, you may benefit from reduced side effects to Pradaxa and many other drugs.

 

Contributors to this Article:
Michael Sapko, MD, PhD; Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® pharmacogenetic testing