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Side Effects of Repaglinide (Prandin)


Side Effects of Repaglinide (Prandin)

Repaglinide, referred as the brand Prandin, is a drug in the meglitinides class. It is commonly used to treat type II diabetes. Prandin has little effect on insulin release. Instead, it works by increasing the glucoses on potassium channels. It takes a number of months for Prandin to have effects on fasting blood glucose levels.

Serious Side Effects

According to the FDA, Prandin’s severe side effects are hypoglycemia (low blood sugar), ischemia (when blood flow is reduced causing the heart muscle to weaken), and angina (chest pain).

Common Side Effects

The common side effects associated with Prandin treatment are:


  • Allergies
  • Headaches
  • Sinus infection
  • Runny nose
  • Bronchitis (chest inflammation)
  • Urinary tract infection
  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Dyspepsia (indigestion)
  • Paresthesia (abnormal tingling, prickling, and burning sensation)
  • Joint pain
  • Back pain


(Prandin label reported by the FDA).

Less Common Side Effects

The FDA also outlines the rare side effects of Prandin:


  • Hypertension (abnormal high blood pressure)
  • Heart attack
  • Arrhythmias (irregular patterns of heartbeats)
  • Palpitations
  • Rashes
  • Hives)
  • Severe itching
  • Raised ALT/AST and is a sign of liver damage)
  • Alopecia (loss of hair)

About Pharmacogenetic Testing

Pharmacogenetics, the study of how an individual’s genes interacts with the medication they take, has shown polymorphisms in the genes that code for enzymes and receptors that interact with drugs like Prandin can increase or decrease the probability of developing side effects.


For instance, polymorphisms in the enzymes that metabolize Prandin have been associated with lower blood concentrations of the drug. Prandin is metabolized by the cytochrome P450 superfamily of enzymes, specifically the isoenzymes CYP2C8 and CYP3A4. Polymorphisms in CYP2C8 has been shown to increase the metabolism of Prandin. This could increase the probability of patients developing side effects.

Know Your Risk with the Rxight® Genetic Test

MD Labs developed the Rxight® test, which sequences 18 genes involved in drug metabolism to establish how patients are likely to react to hundreds of medications, including Prandin. With this information, patients and prescribers will know ahead of time what dose is safe for them, or if an alternative should be used to avoid serious complications.


Contact us to learn more about the Rxight® test at 1-888-888-1932 or through email at support@Rxight.com.


Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® Genetic Health Testing