Description: Ranolazine, commonly known under its trade name Ranexa, is a drug that inhibits sodium influxes in the heart. The drug is commonly used to treat Angina and can be used as an adjunct to a number of other cardiovascular drugs including ACE inhibitors, beta blockers and calcium channel blockers. Ranexa has anti-anginal effects but how it works in the body is currently unknown. While it does have effects altering sodium levels in heart cells, this does not fully explain its anti-anginal effects.
Common Side Effects
As Ranexa has a number of possible effects on heart cells, and an unknown method of action, it is associated with a number of side effects. According to the Food and Drug Administration, common side effects of ranolazine according to the Ranexa label as reported by the FDA include (occur in more than 1% of patients taking Ranexa):
Less Common Side Effects
Some more uncommon side effects according to the Ranexa label include (occur in less than 1% of patients taking Ranexa):
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MD Labs provides the most comprehensive CLIA-certified pharmacogenetic testing program available, Rxight®, which sequences 18 genes to establish how a patients is likely to react to hundreds of drugs (including Ranexa) across 50 clinically significant medication classes. All that is required for testing is a simple cheek swab of your DNA at a participating pharmacy, after which you will receive a comprehensive review of your results with a pharmacist with expertise in pharmacogenetics.
How Does Pharmacogenetic Testing Work?
This inter-patient variability may be caused by differences in patients genetics. Individual differences in the chemicals in the body that metabolize Ranexa may cause adverse effects in some patients and identifying these gene variants in individuals with PGx testing can therefore aid in clinical decision making. Prescribers can identify poor metabolizers and closely monitor for side effects. They may also adjust the dose of the drug that is prescribed, or find a safer alternative if needed.
Contributors to this Article:
Michael Sapko, MD, PhD; Deborah Kallick, PhD, Medicinal Chemistry
Read more about Rxight® pharmacogenetics