Side Effects of Nategllinide (Starlix)
Nateglinide, commonly referred to by the brand Starlix, is a meglitinide glucose lowering drug. It is normally used in the treatment of type 2 diabetes.
Common Side Effects
The Starlix label reported by the FDA outlines the common side effects:
- Hypoglycemia (decreased blood glucose concentration)
- Upper respiratory tract infections
- Bronchitis (inflammation of the bronchial tubes)
- Abdominal pain
- Dyspepsia (indigestion)
- Urticaria (a raised itchy red rash)
- Nausea and vomitting
- Back pain
- Arthropathy (inflammation of joints)
- Flu symptoms
- Accidental trauma
About Pharmacogenetic Testing
The drug is metabolized by CYP2C9, an isoenzyme that is part of the Cytochrome P450 superfamily of enzymes) and alleles, specifically CYP2C9*3. A study has shown CYP2C9*3 to alter the drug’s pharmacokinetics. An increase in the plasma concentration of Starlix may result in more side effects in a given patient.
This inter-patient variability has a number of underlying reasons. One significant cause of inter-patient variability is the differences in the genetics of each patient. Polymorphisms in genes that encode receptors or enzymes that Starlix interacts with can increase or decrease the probability of a patient suffering adverse reactions.
Know Your Risk with the Rxight® Genetic Test
MD Labs provides the state-of-the-art Rxight® genetic test. Rxight® analyzes 18 genes to establish how patients will react to hundreds of medications including Starlix. Identifying these alleles can aid in clinical decision-making. Physicians can alter the starting dose of the medication when the alleles are known. Healthcare providers can take this genetic information and design a treatment plan with effective medications.
Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry
Read more about Rxight® : What is Pharmacogenetics?