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Side Effects of Nateglinide (Starlix)


Side Effects of Nategllinide (Starlix)

Nateglinide, commonly referred to by the brand Starlix, is a meglitinide glucose lowering drug. It is normally used in the treatment of type 2 diabetes.

Common Side Effects

The Starlix label reported by the FDA outlines the common side effects:


  • Hypoglycemia (decreased blood glucose concentration)
  • Upper respiratory tract infections
  • Bronchitis (inflammation of the bronchial tubes)
  • Coughing
  • Diarrhea
  • Abdominal pain
  • Dyspepsia (indigestion)
  • Urticaria (a raised itchy red rash)
  • Nausea and vomitting
  • Dizziness
  • Back pain
  • Arthropathy (inflammation of joints)
  • Flu symptoms
  • Accidental trauma

About Pharmacogenetic Testing

The drug is metabolized by CYP2C9, an isoenzyme that is part of the Cytochrome P450 superfamily of enzymes) and alleles, specifically CYP2C9*3. A study has shown CYP2C9*3 to alter the drug’s pharmacokinetics. An increase in the plasma concentration of Starlix may result in more side effects in a given patient.


This inter-patient variability has a number of underlying reasons. One significant cause of inter-patient variability is the differences in the genetics of each patient. Polymorphisms in genes that encode receptors or enzymes that Starlix interacts with can increase or decrease the probability of a patient suffering adverse reactions.

Know Your Risk with the Rxight® Genetic Test

MD Labs provides the state-of-the-art Rxight® genetic test. Rxight® analyzes 18 genes to establish how patients will react to hundreds of medications including Starlix. Identifying these alleles can aid in clinical decision-making. Physicians can alter the starting dose of the medication when the alleles are known. Healthcare providers can take this genetic information and design a treatment plan with effective medications.


Have more questions on Rxight®? Contact us at 1-888-888-1932 or email us at support@Rxight.com.


Contributors to this Article:
Michael Sapko, MD, PhD; and Deborah Kallick, PhD, Medicinal Chemistry

Read more about Rxight® : What is Pharmacogenetics?