Precision medicine, also called personalized medicine, is a forward-looking approach to healthcare that takes into account a person’s inherited genetic characteristics, lifestyle and environment to diagnose and treat illness. An important element of precision medicine is pharmacogenetics, which evaluates how a person’s genetic makeup affects response to medication.
Some people get no reaction from a drug; others may suffer unpleasant side effects. Rxight® pharmacogenetic testing examines 60 alleles on 18 genes that are associated with how an individual’s genetic variants affect the assimilation of specific medicines in the body. This knowledge helps clinicians select drugs and doses that reduce the potential for side effects and enhance the therapeutic benefits.
Rxight® Pharmacological Testing and Precision Medicine
Pharmacological testing by Rxight® , allows healthcare practitioners to devise drug therapy regimens that have the potential to provide more effective treatment for a number of medical conditions. Personalized medicine is standard in treatment of diseases like cancer, where both the type of cancer and a person’s genetic makeup are analyzed to devise an effective treatment plan. In addition, genetic testing is recommended for several drugs before they are prescribed. For example, genetic testing is required before prescribing the antiretroviral drug abacavir, which has known serious adverse reactions associated with specific genetic variants.
Recommendations by the Food and Drug Administration for genetic testing and modification of dosages are included on drug dispensing labels of more than 150 medications associated with adverse reactions because of genetic variants. The Clinical Pharmacogenetics Implementation Consortium provides detailed information about individual drugs, the gene variants that are known to affect metabolism of the drug and the FDA recommendations for dosages, testing and use.
Benefits of Rxight® Pharmacological Testing
Rxight® pharmacological testing provides important information to the doctor, patient and dispensing pharmacist about potential adverse reactions and drug efficacy. DNA from a cheek swab is collected and sent to MD Labs.
MD Labs is certified by Clinical Laboratory Improvement Amendments, which sets industry standards for genetic testing. The lab uses open array technology to test for variants on genetic markers that have known interactions with the assimilation of more than 200 prescription and non-prescription drugs, including those used in cardiology, pain management, diabetes, neurology, gastroenterology, cancer, arthritis and psychiatry.
Patients receive a Personalized Medication Review that details the results of testing. A pharmacist certified in pharmacogenetics will interpret the results for the patient. The patient can opt to include the report in their medical records so that physicians and pharmacists can make informed decisions about prescribing medications. The certified pharmacist will contact a patient’s healthcare provider to ensure that the dosages and medicines prescribed are compatible with the patient’s genetic characteristics.
If the clinician knows that a particular drug may produce adverse reactions, another drug can be selected. By eliminating the trial and error method of prescribing medicine, patients may see a reduction in the amount spent on drugs. Adherence to a drug therapy program improves when patients know that the potential for side effects is reduced. Testing needs to be done only once because a person’s genetic characteristics do not change.